High-resolution computed tomography (HRCT) analysis in anti-synthase antibody syndrome with organizing pneumonia

Objective: The organizing pneumonia (OP) pattern is the second most common finding in anti-synthase antibody syndrome (ASS), and nonspecific interstitial pneumonia (NSIP) is the most common finding. This study analysed the OP score changes by semiquantitative and quantitative analysis methods and the correlation between the high-resolution computed tomography (HRCT) indexes and the pulmonary function test parameters (PFTs) in ASS patients.MethodsData from ASS-OP patients admitted to the respiratory department of Ping Jin Hospital from October 2014 to June 2020 were retrospectively reviewed and analysed.ResultsFourteen ASS-OP patients were recruited for this study. (1) In method-1, the consolidation (CO) score and the mean lung attenuation (MA) of poorly aerated and fibrosis lung fields (MAfibrosis) (r=0.56, P=0.04), the ground-glass opacity (GGO) score and the MA of non-aerated lung fields (MAnonaerated) (r=−0.64, P=0.01), and the CO plus the GGO (CG) score and the MAnonaerated (r=−0.59, P=0.03) of the lung fields had liner correlations. In method-2, the GGO score to the MAnonaerated (r=−0.58, P=0.03), and the CG (r=−0.68, P=0.01) score to the MAnonaerated had liner correlations. The FVC% (r=0.68, P=0.01) and FEV1% (r=0.64, P=0.01) to the MAfibrosis had good linear correlations. (2) Compared to the values before treatment, the CO pattern score, volume and weight percentages of the extracted whole lung volume with attenuation values of the nonaerated area (Vnonated%, Wnonaerated%), the volume of poorly aerated and fibrosis lung tissue (Vfibrosis%, Wfibrosis%), the weight percentages of normal aerated lung (Wnormal%), and the MAfibrosis exhibited significant differences during the 3–6 month follow-up period. (AU)

Objetivo: El patrón de neumonía organizada (PNO) es el segundo hallazgo más común en el síndrome de anticuerpos antisintasa (SAA), y la neumonía intersticial inespecífica es el hallazgo más común. Este estudio analizó los cambios en la puntuación de PNO mediante métodos de análisis semicuantitativos y cuantitativos, y la correlación entre los índices de la tomografía computarizada de alta resolución y los parámetros de las pruebas de función pulmonar en pacientes con SAA.MétodosSe revisaron y analizaron retrospectivamente los datos de los pacientes SAA-PNO ingresados en el departamento respiratorio del Hospital Ping Jin desde octubre de 2014 hasta junio de 2020.ResultadosSe reclutaron 14 pacientes SAA-PNO para este estudio. (1) En el método 1, la puntuación de consolidación (PC) y la atenuación pulmonar media (APM) de los campos pulmonares mal aireados y fibrosis (APMfibrosis) (r=0,56; p=0,04), la puntuación de la opacidad del vidrio molido (OVM) y la PC de los campos pulmonares no aireados (APMnoaireado) (r=−0,64; p =0,01), y la PC más la puntuación OVM (PV) y el APMnoaireado de los campos pulmonares tenían correlaciones de revestimiento. En el método 2, la puntuación de OVM para el APMnoaireado (r=−0,58; p =0,03) y la puntuación de PV (r=−0,68; p=0,01) para el APMnoaireado tenían correlaciones de revestimiento. El FVC% (r=0,68; p =0,01) y el FEV1% (r=0,64; p =0,01) a la APMfibrosis tuvieron buenas correlaciones lineales. (2) En comparación con los valores anteriores al tratamiento, la puntuación del patrón de PC, los porcentajes de volumen y peso del volumen pulmonar total extraído con los valores de atenuación del área no aireada (Vnoaireado%, Pnoaireado%), el volumen de tejido pulmonar poco aireado y fibroso (Vfibrosis%, Pfibrosis%), los porcentajes de peso del pulmón aireado normal (Pnormal%) y la APMfibrosis mostraron diferencias significativas durante el período de seguimiento de 3 a 6 meses. (AU)

High-resolution computed tomography (HRCT) analysis in anti-synthase antibody syndrome with organizing pneumonia.

OBJECTIVE: The organizing pneumonia (OP) pattern is the second most common finding in anti-synthase antibody syndrome (ASS), and nonspecific interstitial pneumonia (NSIP) is the most common finding. This study analysed the OP score changes by semiquantitative and quantitative analysis methods and the correlation between the high-resolution computed tomography (HRCT) indexes and the pulmonary function test parameters (PFTs) in ASS patients. METHODS: Data from ASS-OP patients admitted to the respiratory department of Ping Jin Hospital from October 2014 to June 2020 were retrospectively reviewed and analysed. RESULTS: Fourteen ASS-OP patients were recruited for this study. (1) In method-1, the consolidation (CO) score and the mean lung attenuation (MA) of poorly aerated and fibrosis lung fields (MAfibrosis) (r=0.56, P=0.04), the ground-glass opacity (GGO) score and the MA of non-aerated lung fields (MAnonaerated) (r=-0.64, P=0.01), and the CO plus the GGO (CG) score and the MAnonaerated (r=-0.59, P=0.03) of the lung fields had liner correlations. In method-2, the GGO score to the MAnonaerated (r=-0.58, P=0.03), and the CG (r=-0.68, P=0.01) score to the MAnonaerated had liner correlations. The FVC% (r=0.68, P=0.01) and FEV1% (r=0.64, P=0.01) to the MAfibrosis had good linear correlations. (2) Compared to the values before treatment, the CO pattern score, volume and weight percentages of the extracted whole lung volume with attenuation values of the nonaerated area (Vnonated%, Wnonaerated%), the volume of poorly aerated and fibrosis lung tissue (Vfibrosis%, Wfibrosis%), the weight percentages of normal aerated lung (Wnormal%), and the MAfibrosis exhibited significant differences during the 3-6 month follow-up period. CONCLUSION: The GGO and CO scored by the semiquantitative or quantitative analysis methods was similar. The HRCT quantitative analysis parameters showed a good correlation with the PFTs in ASS-OP patients, can provide an accurate OP pattern interpretation, and may be used as a monitoring and therapeutic indicator for ASS-OP patients.